A cuproptosis-related lncRNA signature for predicting prognosis and immune response in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) has a high incidence and poor prognosis. Cuproptosis is a novel type of cell death, which differs from previously reported types of cell death such as apoptosis, autophagy, proptosis, ferroptosis, necroptosis, etc. Long non-coding RNAs (lncRNAs) play multiple roles in HCC.

Methods

We downloaded information from The Cancer Genome Atlas (TCGA) database, and obtained cuproptosis-related genes from published studies. The cuproptosis-related lncRNAs were obtained by correlation analysis, and subsequently used to construct a prognostic cuproptosis-related lncRNA signature. Analyses of overall survival (OS), progression-free survival (PFS), receiver operating characteristic (ROC) curve with the area under the curve (AUC) values and the inde

SUBMITTER: Wu J 

PROVIDER: S-EPMC10558351 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature