Mechanical stress confers nuclear and functional changes in derived leukemia cells from persistent confined migration.

ABSTRACT: Nuclear deformability plays a critical role in cell migration. During this process, the remodeling of internal components of the nucleus has a direct impact on DNA damage and cell behavior; however, how persistent migration promotes nuclear changes leading to phenotypical and functional consequences remains poorly understood. Here, we described that the persistent migration through physical barriers was sufficient to promote permanent modifications in migratory-altered cells. We found that derived cells from confined migration showed changes in lamin B1 localization, cell morphology and transcription. Further analysis confirmed that migratory-altered cells showed functional differences in DNA repair, cell response to chemotherapy and cell migration in vivo homing experiments. Experimental

SUBMITTER: de Lope-Planelles A 

PROVIDER: S-EPMC10558412 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature