A robust panel based on genomic methylation sites for recurrence-free survival in early hepatocellular carcinoma.

ABSTRACT:

Purpose

Altered gene methylation precedes altered gene expression and the onset of disease. This study aimed to develop a potential model for predicting recurrence of early to mid-stage hepatocellular carcinoma (HCC) using methylation loci.

Methods

We used data from early to mid-stage HCC patients (TNM I-II) in the TCGA-LIHC dataset and lasso-cox regression model to identify an 18-DNA methylation site panel from which to calculate the riskScore of patients. The correlation of high/low riskScore with recurrence-free survival (RFS) and immune microenvironment in HCC patients was analyzed by bioinformatics. It was also validated in the GSE56588 dataset and the final dynamic nomogram was constructed.

Results

The results showed that riskScore was significantly correlated w

SUBMITTER: Long G 

PROVIDER: S-EPMC10558510 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature