SARS-CoV-2 spike-specific T_FH cells exhibit unique responses in infected and vaccinated individuals.

ABSTRACT: Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb) and B cell differentiation are tightly regulated by T follicular help (T_FH) cells. However, the longevity and functional role of T_FH cell subsets in COVID-19 convalescents and vaccine recipients remain poorly defined. Here, we show that SARS-CoV-2 infection and inactivated vaccine elicited both spike-specific CXCR3⁺ T_FH cell and CXCR3^- T_FH cell responses, which showed distinct response patterns. Spike-specific CXCR3⁺ T_FH cells exhibit a dominant and more durable response than CXCR3^- T_FH cells that positively correlated with antibody responses. A third boos

SUBMITTER: He R 

PROVIDER: S-EPMC10558553 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature