Ontology highlight
ABSTRACT:
SUBMITTER: Miwa N
PROVIDER: S-EPMC10558574 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Miwa Naofumi N Hanaue Mayu M Aoba Kayo K Saito Ryohei R Takamatsu Ken K
Communications biology 20231006 1
Metastasis, a multistep process including cancer cell migration and invasion, is the major cause of mortality in patients with cancer. Here, we investigated the effect of dicalcin, a Ca<sup>2+</sup>-binding protein, on the invasion and metastasis of ovarian cancer (OC) cells. Extracellularly administered dicalcin bound to the membrane of OV2944 cells, mouse OC cells, and suppressed their migration in vitro; however, cell viability or proliferation were unaffected. Repeated intraperitoneal inject ...[more]