Association of common infections with cognitive performance in the Baltimore Epidemiologic Catchment Area study follow-up.

ABSTRACT:

Introduction

Growing evidence suggests that some common infections are causally associated with cognitive impairment; however, less is known about the burden of multiple infections.

Methods

We investigated the cross-sectional association of positive antibody tests for herpes simplex virus, cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella zoster virus (VZV), and Toxoplasma gondii (TOX) with Mini-Mental State Examination (MMSE) and delayed verbal recall performance in 575 adults aged 41-97 from the Baltimore Epidemiologic Catchment Area Study.

Results

In multivariable-adjusted zero-inflated Poisson (ZIP) regression models, positive antibody tests for CMV (p = .011) and herpes simplex virus (p = .018) were individually associated with poorer MMSE performance (p

SUBMITTER: Wennberg AM 

PROVIDER: S-EPMC10558626 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature