Supervised clustering of peripheral immune cells associated with clinical response to checkpoint inhibitor therapy in patients with advanced melanoma.

ABSTRACT:

Background and purpose

Immune therapy with checkpoint inhibitors (CPIs) is a highly successful therapy in many cancers including metastatic melanoma. Still, many patients do not respond well to therapy and there are no blood-borne biomarkers available to assess the clinical outcome.

Materials and methods

To investigate cellular changes after CPI therapy, we carried out flow cytometry-based immune monitoring in a cohort of 90 metastatic melanoma patients before and after CPI therapy using the FlowSOM algorithm. To evaluate associations to the clinical outcome with therapy, we divided the patients based on progression-free survival.

Results

We found significant associations with CPI therapy in both peripheral blood mononuclear cell and T-cell subsets, but with the most

SUBMITTER: Kverneland AH 

PROVIDER: S-EPMC10558712 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature