Ontology highlight
ABSTRACT:
SUBMITTER: Wilkinson AL
PROVIDER: S-EPMC10558774 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Wilkinson Alex L AL Hulme Samuel S Kennedy James I JI Mann Emily R ER Horn Paul P Shepherd Emma L EL Yin Kelvin K Zaki Marco Y W MYW Hardisty Gareth G Lu Wei-Yu WY Rantakari Pia P Adams David H DH Salmi Marko M Hoare Matthew M Patten Daniel A DA Shetty Shishir S
iScience 20230919 10
Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a vascular barrier and gatekeeper for immune cell recruitment are poorly understood. Plasmalemma-vesicle-associated protein (PLVAP) has been characterized as a marker of LSEC in CLD; notably we found that PLVAP upregulation strongly correlated with markers of tissue senescence. Furthermore, exposure of huma ...[more]