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Sex-related incidence and survival differences in pediatric high-grade glioma subtypes: A population-based cohort study.


ABSTRACT: Not much is known on sex differences in incidence, survival, and treatment characteristics for midline and hemispheric pHGGs. This population-based study confirms previously reported study results that found worse survival outcomes for malignant diffuse gliomas in girls in the age group 0-9 years. Additionally, in our study we pinpoint this difference to girls with midline pHGGs aged 0-4 years. We provide insight in the possible underlying mechanisms contributing to sex survival differences in pHGG patients. With first line treatment having no impact on the higher risk of dying for girls, but age and tumor characteristics having a neutralizing effect. The results of this population-based study serve as a basis for future pre-clinical and clinical studies to further unravel the underlying mechanisms responsible for the survival gap between sexes in midline pHGG.

SUBMITTER: Hoogendijk R 

PROVIDER: S-EPMC10558809 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Sex-related incidence and survival differences in pediatric high-grade glioma subtypes: A population-based cohort study.

Hoogendijk Raoull R   van der Lugt Jasper J   Baugh Josh J   Kline Cassie C   Kranendonk Mariette M   Hoving Eelco E   Kremer Leontien L   Wesseling Pieter P   Karim-Kos Henrike H   van Vuurden Dannis D  

iScience 20230917 10


Not much is known on sex differences in incidence, survival, and treatment characteristics for midline and hemispheric pHGGs. This population-based study confirms previously reported study results that found worse survival outcomes for malignant diffuse gliomas in girls in the age group 0-9 years. Additionally, in our study we pinpoint this difference to girls with midline pHGGs aged 0-4 years. We provide insight in the possible underlying mechanisms contributing to sex survival differences in p  ...[more]

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