Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design.

ABSTRACT: Ovarian cancer (OC) is highly lethal due to late detection and frequent recurrence. Initial treatments, comprising surgery and chemotherapy, lead to disease remission but are invariably associated with subsequent relapse. The identification of novel therapies and an improved understanding of the molecular and cellular characteristics of OC are urgently needed. Here, we conducted a comprehensive analysis of primary tumor cells and their microenvironment from 16 chemonaive and 10 recurrent OC patient samples. Profiling OC tumor biomarkers allowed for the identification of potential molecular targets for developing immunotherapies, while profiling the microenvironment yielded insights into its cellular composition and property changes between chemonaive and recurrent samples. Notably, we iden

SUBMITTER: Li YR 

PROVIDER: S-EPMC10558812 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature