Field performance and cost-effectiveness of a point-of-care triage test for HIV virological failure in Southern Africa.

ABSTRACT:

Introduction

Antiretroviral therapy (ART) monitoring using viral load (VL) testing is challenging in high-burden, limited-resources settings. Chemokine IP-10 (interferon gamma-induced protein 10) strongly correlates with human immunodeficiency virus (HIV) VL. Its determination could serve to predict virological failure (VF) and to triage patients requiring VL testing. We assessed the field performance of a semi-quantitative IP-10 lateral flow assay (LFA) for VF screening in South Africa, and the cost-effectiveness of its implementation in Mozambique.

Methods

A cross-sectional study was conducted between June and December 2021 in three primary health clinics in the Western Cape. Finger prick capillary blood was collected from adults on ART for ≥1 year for direct application o

SUBMITTER: Saura-Lazaro A 

PROVIDER: S-EPMC10558896 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature