Role of LncRNA MIR99AHG in breast cancer: Bioinformatic analysis and preliminary verification.

ABSTRACT:

Objective

This research was aimed to preliminarily explore the clinical roles and potential molecular mechanisms of MIR99AHG and its significant transcripts in breast cancer (BRCA).

Methods

Public databases were utilized to analyze the expression and prognostic roles of MIR99AHG and its transcripts. Relationships between MIR99AHG expression and immune cells infiltration were analyzed in Xiantao platform. In addition, co-expressed genes and interacting proteins of MIR99AHG were predicted. CancerSEA analyzed its relationship with functional states. Next, CNV status, DNA methylation, interacting transcription factors (TFs) and ceRNA network were analyzed to explore its possible mechanisms. Then, RNA ISH and FISH assays were used to detect its expression and location in BRCA tis

SUBMITTER: Han W 

PROVIDER: S-EPMC10559167 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature