Dietary intake and incidence risk of idiopathic pulmonary fibrosis: a Mendelian randomization study.

ABSTRACT:

Background

Dietary intake has been shown to have a causal relationship with various lung diseases, such as lung cancer and asthma. However, the causal relationship between dietary intake and idiopathic pulmonary fibrosis (IPF) remains unclear. We conducted a two-sample Mendelian Randomization (MR) study to investigate the causal relationship between dietary intake and IPF.

Methods

The exposure datasets included meat, fruit, vegetable, and beverage intake from the UK Biobank. IPF data came from the EBI database of 451,025 individuals. All data in this study were obtained from the IEU Open GWAS Project. The inverse variance weighted (IVW), MR-Egger, and weighted median methods were used as the primary methods. Sensitivity analyses were performed to ensure the validity of the r

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10559423 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature