Impact of GADD45A on Radiation Biodosimetry Using Mouse Peripheral Blood.

ABSTRACT: High-dose-radiation exposure in a short period of time leads to radiation syndromes characterized by severe acute and delayed organ-specific injury accompanied by elevated organismal morbidity and mortality. Radiation biodosimetry based on gene expression analysis of peripheral blood is a valuable tool to detect exposure to radiation after a radiological/nuclear incident and obtain useful biological information that could predict tissue and organismal injury. However, confounding factors, including chronic inflammation, can potentially obscure the predictive power of the method. GADD45A (Growth arrest and DNA damage-inducible gene a) plays important roles in cell growth control, differentiation, DNA repair, and apoptosis. GADD45A-deficient mice develop an autoimmune disease, similar to hum

SUBMITTER: Broustas CG 

PROVIDER: S-EPMC10559452 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature