Synergistic antibacterial action of the iron complex and ampicillin against Staphylococcus aureus.

ABSTRACT:

Objectives

Resistance to antibiotics among bacteria of clinical importance, including Staphylococcus aureus, is a serious problem worldwide and the search for alternatives is needed. Some metal complexes have antibacterial properties and when combined with antibiotics, they may increase bacterial sensitivity to antimicrobials. In this study, we synthesized the iron complex and tested it in combination with ampicillin (Fe16 + AMP) against S. aureus.

Methods

An iron complex (Fe16) was synthesized and characterized using spectroscopy methods. Confirmation of the synergistic effect between the iron complex (Fe16) and ampicillin (AMP) was performed using ζ-potential, infrared spectra and FICI index calculated from the minimum inhibitory concentration (MIC) from the checkerboard a

SUBMITTER: Kosaristanova L 

PROVIDER: S-EPMC10559456 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature