Causal relationship between blood metabolites and risk of five infections: a Mendelian randomization study.

ABSTRACT:

Objective

Infectious diseases continue to pose a significant threat in the field of global public health, and our understanding of their metabolic pathogenesis remains limited. However, the advent of genome-wide association studies (GWAS) offers an unprecedented opportunity to unravel the relationship between metabolites and infections.

Methods

Univariable and multivariable Mendelian randomization (MR) was commandeered to elucidate the causal relationship between blood metabolism and five high-frequency infection phenotypes: sepsis, pneumonia, upper respiratory tract infections (URTI), urinary tract infections (UTI), and skin and subcutaneous tissue infection (SSTI). GWAS data for infections were derived from UK Biobank and the FinnGen consortium. The primary analysis was co

SUBMITTER: Wei Z 

PROVIDER: S-EPMC10559484 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature