Genetically predicted obstructive sleep apnea is causally associated with an increased risk for periodontitis.

ABSTRACT:

Background

Although obstructive sleep apnea (OSA) and periodontitis are associated, whether this association is causative is uncertain.

Methods

We conducted a bidirectional Mendelian randomization (MR) analysis using data from publically accessible genome-wide association studies. The single-nucleotide polymorphisms (SNPs) for OSA were derived from 16,761 cases and 201,194 controls. The pooled data of periodontitis association involved up to 17,353 individuals. Disease-associated single-nucleotide polymorphisms were selected as an instrumental variable at the genome-wide significance level (p < 5.0 × 10^- 6). Subsequently, the causal effects were estimated using three different methods: inverse variance weighting (IVW), MR-Egger, and weighted median. Then, these ca

SUBMITTER: Mi Z 

PROVIDER: S-EPMC10559524 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature