Effects of iron homeostasis on epigenetic age acceleration: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Epigenetic clocks constructed from DNA methylation patterns have emerged as excellent predictors of aging and aging-related health outcomes. Iron, a crucial element, is meticulously regulated within organisms, a phenomenon referred as iron homeostasis. Previous researches have demonstrated the sophisticated connection between aging and iron homeostasis. However, their causal relationship remains relatively unexplored.

Results

Through two-sample Mendelian randomization (MR) utilizing the random effect inverse variance weighted (IVW) method, each standard deviation (SD) increase in serum iron was associated with increased GrimAge acceleration (GrimAA, Beta_IVW = 0.27, P = 8.54E-03 in 2014 datasets; Beta_IVW = 0.31, P = 1.25E-02 in 2021 datasets),

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10559596 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature