Helicobacter pylori infection increases the risk of carotid plaque formation: Clinical samples combined with bioinformatics analysis.

ABSTRACT:

Objective

Infection with Helicobacter pylori (H. pylori) may increase atherosclerosis, which can lead to carotid plaque formation. Our study examined the relationship between H. pylori infection and carotid plaque formation, and its underlying mechanisms.

Methods

A total of 36,470 people who underwent physical examination in Taizhou Hospital Health Examination Center from June 2017 to June 2022 were included in this study. All people participated in the urease test, neck ultrasound, blood pressure detection, anthropometric measurement and biochemical laboratory examination. In addition, the GSE27411 and GSE28829 datasets in the Gene Expression Omnibus (GEO) database were used to analyze the mechanism of H. pylori infection and atherosclerosis prog

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10559771 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature