Potential effects of gingerol topical application on components of the innate immunity in lactating goat mammary glands.

ABSTRACT: In the mammary glands, production of antimicrobial components and formation of less-permeable tight junctions (TJs) are important for safe milk production. Previously, we reported that local heat treatment of udders using disposable heating pad enhances the components of innate immunity in lactating goat mammary glands. Gingerol is a polyphenol present in ginger that can induce heat-like effects. However, oral administration of polyphenols causes a decrease in biological activity through conjugation and metabolic conversion. Here, we investigated the effects of gingerol on antimicrobial components and TJs by topically applying it to lactating goat udders. Gingerol application increased the somatic cell count, cathelicidin-2 concentration, and proportion of polymorphonuclear cells in the mi

SUBMITTER: Tsugami Y 

PROVIDER: S-EPMC10559874 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature