Efficacy and safety of azvudine in patients with COVID-19: A systematic review and meta-analysis.

ABSTRACT:

Introduction

Azivudine has undergone a few randomized controlled trials (RCTs) as of late. This study aimed to assess the COVID-19 treatment with azvudine's efficacy and safety.

Methods

Through January 20, 2023, systematic searches of PubMed, Embase, ClinicalTrials.gov, International Clinical Trials Registry Platform (ICTRP), Cochrane Central Register of Controlled Trials (CENTRAL), and MedRxiv were conducted to find the RCTs. The included studies' bias risk was evaluated using the Cochrane Handbook for Systematic Reviews of Interventions. Meta-analysis was performed using Revman 5.4 (PROSPERO Code: CRD42023395022).

Results

A total of five RCTs with 1142 COVID-19 patients, 575 of whom received azvudine, were included. Additionally, seven RCTs are currently being condu

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10559905 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature