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Antimetastatic activity of seongsanamide B in γ-irradiated human lung cancer.

ABSTRACT: Lung cancer, which has a high incidence and mortality rates, often metastasizes and exhibits resistance to radiation therapy. Seongsanamide B has conformational features that suggest it has therapeutic potential; however, its antitumor activity has not yet been reported. We evaluated the possibility of seongsanamide B as a radiation therapy efficiency enhancer to suppress γ-irradiation-induced metastasis in non-small cell lung cancer. Seongsanamide B suppressed non-small cell lung cancer cell migration and invasion caused by γ-irradiation. Furthermore, it suppressed γ-irradiation-induced upregulation of Bcl-X_L and its downstream signaling molecules, such as superoxide dismutase 2 (SOD2) and phosphorylated Src, by blocking the nuclear translocation of phosphorylated STAT3. Additionally, seongsanamide B markedly modulated the γ-irradiation-induced upregulation of E-cadherin and vimentin. Consistent with the results obtained in vitro, while seongsanamide B did not affect xenograft tumor growth, it significantly suppressed γ-irradiation-induced metastasis by inhibiting Bcl-X_L/SOD2/phosphorylated-Src expression and modulating E-cadherin and vimentin expression in a mouse model. Thus, seongsanamide B may demonstrate potential applicability as a radiation therapy efficiency enhancer for lung cancer treatment.

SUBMITTER: Ryoo GH

PROVIDER: S-EPMC10559954 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Antimetastatic activity of seongsanamide B in γ-irradiated human lung cancer.

Ryoo Ga-Hee GH Kim Geum Jin GJ Han Ah-Reum AR Jin Chang Hyun CH Lee Hunmin H Nam Joo-Won JW Choi Hyukjae H Jung Chan-Hun CH

Heliyon 20230914 9

Lung cancer, which has a high incidence and mortality rates, often metastasizes and exhibits resistance to radiation therapy. Seongsanamide B has conformational features that suggest it has therapeutic potential; however, its antitumor activity has not yet been reported. We evaluated the possibility of seongsanamide B as a radiation therapy efficiency enhancer to suppress γ-irradiation-induced metastasis in non-small cell lung cancer. Seongsanamide B suppressed non-small cell lung cancer cell mi ...[more]

PMID: 37809399

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Dataset Information

Antimetastatic activity of seongsanamide B in γ-irradiated human lung cancer.

Publications

Antimetastatic activity of seongsanamide B in γ-irradiated human lung cancer.

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