Genes encoding teleost orthologues of human signal transduction proteins remain duplicated or triplicated more frequently than the whole genome.

ABSTRACT: Cell signalling involves a myriad of proteins, many of which belong to families of related proteins, and these proteins display a huge number of interactions. One of the events that has led to the creation of new genes is whole genome duplication (WGD), a phenomenon that has made some major innovations possible. In addition to the two WGDs that happened before gnathostome radiation, teleost genomes underwent one (the 3WGD group) or two (the 4WGD group) extra WGD after separation from the lineage leading to holostei. In the present work, we studied in 63 teleost species whether the orthologues of human genes involved in 47 signalling pathways (HGSP) remain more frequently duplicated, triplicated or in the singleton state compared with the whole genome. We found that these genes have remaine

SUBMITTER: Picolo F 

PROVIDER: S-EPMC10559978 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature