COVID-19 susceptibility and severity for dyslipidemia: A mendelian randomization investigation.

ABSTRACT:

Background

The severe acute respiratory syndrome coronavirus in 2019 (COVID-19) is still spreading and causing deaths worldwide, which further increased the burden of chronic diseases. Dyslipidemia is a common metabolic syndrome, which is a major risk factor for cardiovascular disease. However, studies on whether there is a direct causal relationship between COVID-19 and the exacerbation of hyperlipidemia are still scarce.

Methods

Two-sample Mendelian randomization was conducted using publicly available summary statistics from independent cohorts of European ancestry. For COVID-19 and hyperlipidemia, we used data from the ieu open GWAS project database. Inverse variance-weighted, mendelian randomization Egger, weighted median, simple mode, and weighted mode mendelian randomi

SUBMITTER: Liang Y 

PROVIDER: S-EPMC10560011 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature