Alterations of gut microbiota and metabolome in early chronic kidney disease patients complicated with hyperuricemia.

ABSTRACT:

Object

This study aims to investigate the changes in gut microbiota and metabolism of patients with chronic kidney disease (CKD) stage 1-2, as well as the potential impact of hyperuricemia (HUA) on these factors in CKD stage 1-2 patients.

Methods

In this study, fecal samples were collected from CKD stage 1-2 without HUA patients (CKD-N group), CKD stage 1-2 with HUA patients (CKD-H group), and healthy people controls (HCs group). The samples were then subjected to the microbiome (16S rRNA gene sequencing) and metabolome (liquid chromatography-tandem mass spectrometry) analyses. The multi-omics datasets were analyzed individually and integrated for combined analysis using various bioinformatics approaches.

Results

Gut microbial dysbiosis was found in CKD-N and CKD-H pa

SUBMITTER: Liu P 

PROVIDER: S-EPMC10560056 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature