VISTA: visualizing the spatial transcriptome of the C.elegans nervous system.

ABSTRACT:

Summary

Profiling the transcriptomes of single cells without sacrificing spatial information is a major goal of the field of spatial transcriptomics, but current technologies require tradeoffs between single-cell resolution and whole-transcriptome coverage. In one animal species, the nematode worm Caenorhabditis elegans, a comprehensive spatial transcriptome with single-cell resolution is attainable using existing datasets, thanks to the worm's invariant cell lineage and a series of recently generated single cell transcriptomes. Here we present VISTA, which leverages these datasets to provide a visualization of the worm spatial transcriptome, focusing specifically on the nervous system. VISTA allows users to input a query gene and visualize its expression across all neurons

SUBMITTER: Liska D 

PROVIDER: S-EPMC10560093 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature