Noncoding translation mitigation.

ABSTRACT: Translation is pervasive outside of canonical coding regions, occurring in long noncoding RNAs, canonical untranslated regions and introns^1-4, especially in ageing^4-6, neurodegeneration^5,7 and cancer^8-10. Notably, the majority of tumour-specific antigens are results of noncoding translation^11-13. Although the resulting polypeptides are often nonfunctional, translation of noncoding regions is nonetheless necessary for the birth of new coding sequences^14,15. The mechanisms underlying the surveillance of translation in diverse noncoding regions and how escaped polypeptides evolve new functions remain unclear^10,16-19. Functional polypeptides derived from annotated noncoding sequences often localize to membranes²⁰

SUBMITTER: Kesner JS 

PROVIDER: S-EPMC10560126 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature