The plasma exosomes from patients with primary Sjogren's syndrome contain epithelial cell-derived proteins involved in ferroptosis.

ABSTRACT: Primary Sjögren's syndrome (pSS) is an autoimmune disease represented by exocrine gland epithelial cell lesions. However, the mechanism underlying these lesions remains unclear. This study analyzed the plasma exosomes of pSS patients using proteomics and revealed the presence of 24 differentially expressed proteins (DEPs) involved in the primary biological processes and signaling pathways related to ferroptosis. The DEPs enriched in the ferroptosis-related items were represented by downregulated ceruloplasmin (CP) and transferrin (TF). CC analysis of GO enrichment showed that CP and TF were localized at the apical plasma membrane, which is currently found only in epithelial cells. PPI analysis indicated that these exosomal DEPs formed a clustering network containing CP and TF. Among them,

SUBMITTER: Peng X 

PROVIDER: S-EPMC10560162 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature