SPP1/osteopontin: a driver of fibrosis and inflammation in degenerative ascending aortic aneurysm?

ABSTRACT: Degenerative ascending aortic aneurysm (AscAA) is a silent and potentially fatal disease characterized by excessive vascular inflammation and fibrosis. We aimed to characterize the cellular and molecular signature for the fibrotic type of endothelial mesenchymal transition (EndMT) that has previously been described in degenerative AscAA. Patients undergoing elective open-heart surgery for AscAA and/or aortic valve repair were recruited. Gene expression in the intima-media of the ascending aorta was measured in 22 patients with non-dilated and 24 with dilated aortas, and candidate genes were identified. Protein expression was assessed using immunohistochemistry. Interacting distal gene enhancer regions were identified using targeted chromosome conformation capture (HiCap) in untreated and L

SUBMITTER: Freiholtz D 

PROVIDER: S-EPMC10560177 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature