Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression.

ABSTRACT: Recent evidence demonstrates potential links between mitochondrial dysfunction and inflammatory bowel diseases (IBD). In addition, bidirectional interactions between the intestinal microbiota and host mitochondria may modulate intestinal inflammation. We observed previously that mice deficient in the mitochondrial protein MCJ (Methylation-controlled J protein) exhibit increased susceptibility to DSS colitis. However, it is unclear whether this phenotype is primarily driven by MCJ^-/- associated gut microbiota dysbiosis or by direct effects of MCJ-deficiency. Here, we demonstrate that fecal microbiota transplantation (FMT) from MCJ-deficient into germ-free mice was sufficient to confer increased susceptibility to colitis. Therefore, an FMT experiment by cohousing was designed to a

SUBMITTER: Pena-Cearra A 

PROVIDER: S-EPMC10560208 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature