Ecological network analysis reveals cancer-dependent chaperone-client interaction structure and robustness.

ABSTRACT: Cancer cells alter the expression levels of metabolic enzymes to fuel proliferation. The mitochondrion is a central hub of metabolic reprogramming, where chaperones service hundreds of clients, forming chaperone-client interaction networks. How network structure affects its robustness to chaperone targeting is key to developing cancer-specific drug therapy. However, few studies have assessed how structure and robustness vary across different cancer tissues. Here, using ecological network analysis, we reveal a non-random, hierarchical pattern whereby the cancer type modulates the chaperones' ability to realize their potential client interactions. Despite the low similarity between the chaperone-client interaction networks, we highly accurately predict links in one cancer type based on anoth

SUBMITTER: Galai G 

PROVIDER: S-EPMC10560210 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature