Immediate neural impact and incomplete compensation after semantic hub disconnection.

ABSTRACT: The human brain extracts meaning using an extensive neural system for semantic knowledge. Whether broadly distributed systems depend on or can compensate after losing a highly interconnected hub is controversial. We report intracranial recordings from two patients during a speech prediction task, obtained minutes before and after neurosurgical treatment requiring disconnection of the left anterior temporal lobe (ATL), a candidate semantic knowledge hub. Informed by modern diaschisis and predictive coding frameworks, we tested hypotheses ranging from solely neural network disruption to complete compensation by the indirectly affected language-related and speech-processing sites. Immediately after ATL disconnection, we observed neurophysiological alterations in the recorded frontal and audit

SUBMITTER: Kocsis Z 

PROVIDER: S-EPMC10560235 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature