PET imaging and quantification of small animals using a clinical SiPM-based camera.

ABSTRACT:

Background

Small-animal PET imaging is an important tool in preclinical oncology. This study evaluated the ability of a clinical SiPM-PET camera to image several rats simultaneously and to perform quantification data analysis.

Methods

Intrinsic spatial resolution was measured using 18F line sources, and image quality was assessed using a NEMA NU 4-2018 phantom. Quantification was evaluated using a fillable micro-hollow sphere phantom containing 4 spheres of different sizes (ranging from 3.95 to 7.86 mm). Recovery coefficients were computed for the maximum (Amax) and the mean (A50) pixel values measured on a 50% isocontour drawn on each sphere. Measurements were performed first with the phantom placed in the centre of the field of view and then in the off-centre position with

SUBMITTER: Desmonts C 

PROVIDER: S-EPMC10560240 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature