Homologous Pairs of Low and High Temperature Originating Proteins Spanning the Known Prokaryotic Universe.

ABSTRACT: Stability of proteins at high temperature has been a topic of interest for many years, as this attribute is favourable for applications ranging from therapeutics to industrial chemical manufacturing. Our current understanding and methods for designing high-temperature stability into target proteins are inadequate. To drive innovation in this space, we have curated a large dataset, learn2thermDB, of protein-temperature examples, totalling 24 million instances, and paired proteins across temperatures based on homology, yielding 69 million protein pairs - orders of magnitude larger than the current largest. This important step of pairing allows for study of high-temperature stability in a sequence-dependent manner in the big data era. The data pipeline is parameterized and open, allowing it t

SUBMITTER: Komp E 

PROVIDER: S-EPMC10560248 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature