Advances in chemoablation in upper tract urothelial carcinoma: overview of indications and treatment patterns.

ABSTRACT: Localized upper tract urothelial carcinoma (UTUC) is a difficult disease for clinicians to treat, due to the multitude of oncological and patient factors to consider. Despite the challenges of diagnostic staging, endoscopic management, and disease recurrence, there is still a need for local therapeutic options that do not subject patients to the morbidities of radical nephroureterectomy (RNU). Intraluminal chemotherapies have allowed for improved oncological control in patients with low-grade disease receiving renal-sparing treatment approaches. This narrative review discusses the treatment modalities available for localized low-grade UTUC, with a focus on the current status of chemoablation. The OLYMPUS trial was a pivotal study that lead to the Food and Drug Administration (FDA) approval

SUBMITTER: Gottlieb J 

PROVIDER: S-EPMC10560338 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature