Conserved and tissue-specific immune responses to biologic scaffold implantation.

ABSTRACT: Upon implantation into a patient, any biomaterial induces a cascade of immune responses that influences the outcome of that device. This cascade depends upon several factors, including the composition of the material itself and the location in which the material is implanted. There is still significant uncertainty around the role of different tissue microenvironments in the immune response to biomaterials and how that may alter downstream scaffold remodeling and integration. In this study, we present a study evaluating the immune response to decellularized extracellular matrix materials within the intraperitoneal cavity, the subcutaneous space, and in a traumatic skeletal muscle injury microenvironment. All different locations induced robust cellular recruitment, specifically of macrophage

SUBMITTER: DeStefano S 

PROVIDER: S-EPMC10560402 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature