The role of systemic statins in the inception and healing of apical periodontitis: a systematic review.

ABSTRACT:

Objectives

Statins are a category of medications widely used to reduce plasma LDL-cholesterol levels, that also possess antibacterial, anti-inflammatory, and immunomodulatory action. The aim of this systematic review was to explore the effects of systemic statins therapy on the development and treatment of apical periodontitis (AP) on humans and animals.

Material and methods

Three electronic databases (PubMed, Web of Science, and Scopus) and grey literature were searched from their inception until February, 20 2023 (PROSPERO CRD42021246231). For the quality assessment and risk of bias, different guidelines were used according to the typology of the studies considered (Animal Research Reporting of In Vivo Experiments, Newcastle-Ottawa Quality Assessment Form for Cohort Studie

SUBMITTER: Ideo F 

PROVIDER: S-EPMC10560424 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature