Stabilizing histamine release in gut mast cells mitigates peripheral and central inflammation after stroke.

ABSTRACT: Stroke is the most common cause of long-term disability and places a high economic burden on the global healthcare system. Functional outcomes from stroke are largely determined by the extent of ischemic injury, however, there is growing recognition that systemic inflammatory responses also contribute to outcomes. Mast cells (MCs) rapidly respond to injury and release histamine (HA), a pro-inflammatory neurotransmitter that enhances inflammation. The gut serves as a major reservoir of HA. We hypothesized that cromolyn, a mast cell stabilizer that prevents the release of inflammatory mediators, would decrease peripheral and central inflammation, reduce MC trafficking to the brain, and improve stroke outcomes. We used the transient middle cerebral artery occlusion (MCAO) model of ischemic st

SUBMITTER: Conesa MPB 

PROVIDER: S-EPMC10560441 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature