Generation and propagation of bursts of activity in the developing basal ganglia.

ABSTRACT: The neonatal brain is characterized by intermittent bursts of oscillatory activity interspersed by relative silence. Although well-characterized for many cortical areas, to what extent these propagate and interact with subcortical brain areas is largely unknown. Here, early network activity was recorded from the developing basal ganglia, including motor/somatosensory cortex, dorsal striatum, and intralaminar thalamus, during the first postnatal weeks in mice. An unsupervised detection and classification method revealed two main classes of bursting activity, namely spindle bursts and nested gamma spindle bursts, characterized by oscillatory activity at ~ 10 and ~ 30 Hz frequencies, respectively. These were reliably identified across all three brain regions and exhibited region-specific diff

SUBMITTER: Klavinskis-Whiting S 

PROVIDER: S-EPMC10560579 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature