Δ9-THC reduces reward-related brain activity in healthy adults.

ABSTRACT:

Rationale

Greater availability of cannabis in the USA has raised concerns about adverse effects of the drug, including possible amotivational states. Lack of motivation may be assessed by examining acute effects of cannabinoids on reward processing.

Objectives

This study examined single doses of delta-9-tetrahydrocannabinol (∆9-THC; 7.5, 15 mg oral) in healthy adults using a version of the monetary incentive delay (MID) task adapted for electroencephalography (EEG; e-MID) in a within-subjects, double blind design.

Methods

Two phases of reward processing were examined: anticipation, which occurs with presentation of cues that indicate upcoming reward, punishment, or neutral conditions, and outcome, which occurs with feedback indicating hits or misses. During anticipati

SUBMITTER: Murray CH 

PROVIDER: S-EPMC10560585 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature