Decreasing incidence of conjunctival squamous cell carcinoma in people with HIV in South Africa.

ABSTRACT:

Background

The main risk factors for squamous cell carcinoma of the conjunctiva (SCCC) are immunodeficiency and exposure to ultraviolet radiation. Little is known about SCCC epidemiology among people with HIV (PWH) in South Africa.

Methods

We used data from the South African HIV Cancer Match study, a nation-wide cohort of PWH in South Africa, created through a privacy-preserving probabilistic record linkage of HIV-related laboratory records from the National Health Laboratory Service and cancer records from the National Cancer Registry from 2004 to 2014. We calculated crude incidence rates, analyzed trends using joinpoint models, and estimated hazard ratios for different risk factors using Royston-Parmar flexible parametric survival models.

Results

Among 5 247 968 PWH

SUBMITTER: Metekoua C 

PROVIDER: S-EPMC10560597 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature