Free and Interfacial Boundaries in Individual-Based Models of Multicellular Biological systems.

ABSTRACT: Coordination of cell behaviour is key to a myriad of biological processes including tissue morphogenesis, wound healing, and tumour growth. As such, individual-based computational models, which explicitly describe inter-cellular interactions, are commonly used to model collective cell dynamics. However, when using individual-based models, it is unclear how descriptions of cell boundaries affect overall population dynamics. In order to investigate this we define three cell boundary descriptions of varying complexities for each of three widely used off-lattice individual-based models: overlapping spheres, Voronoi tessellation, and vertex models. We apply our models to multiple biological scenarios to investigate how cell boundary description can influence tissue-scale behaviour. We find that

SUBMITTER: Germano DPJ 

PROVIDER: S-EPMC10560655 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature