Fitting parameters and therapies of ODE tumor models with senescence and immune system.

ABSTRACT: This work is devoted to introduce and study two quasispecies nonlinear ODE systems that model the behavior of tumor cell populations organized in different states. In the first model, replicative, senescent, extended lifespan, immortal and tumor cells are considered, while the second also includes immune cells. We fit the parameters regulating the transmission between states in order to approximate the outcomes of the models to a real progressive tumor invasion. After that, we study the identifiability of the fitted parameters, by using two sensitivity analysis methods. Then, we show that an adequate reduced fitting process (only accounting to the most identifiable parameters) gives similar results but saving computational cost. Three different therapies are introduced in the models to shr

SUBMITTER: Guillen-Gonzalez F 

PROVIDER: S-EPMC10560657 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature