Model-free idealization: Adaptive integrated approach for idealization of ion-channel currents.

ABSTRACT: Single-channel electrophysiological recordings provide insights into transmembrane ion permeation and channel gating mechanisms. The first step in the analysis of the recorded currents involves an "idealization" process, in which noisy raw data are classified into two discrete levels corresponding to the open and closed states of channels. This provides valuable information on the gating kinetics of ion channels. However, the idealization step is often challenging in cases of currents with poor signal-to-noise ratios and baseline drifts, especially when the gating model of the target channel is not identified. We report herein on a highly robust model-free idealization method for achieving this goal. The algorithm, called adaptive integrated approach for idealization of ion-channel current

SUBMITTER: Sato M 

PROVIDER: S-EPMC10560676 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature