Common methodological pitfalls in ICI pneumonitis risk prediction studies.

ABSTRACT:

Background

Pneumonitis is one of the most common adverse events induced by the use of immune checkpoint inhibitors (ICI), accounting for a 20% of all ICI-associated deaths. Despite numerous efforts to identify risk factors and develop predictive models, there is no clinically deployed risk prediction model for patient risk stratification or for guiding subsequent monitoring. We believe this is due to systemic suboptimal approaches in study designs and methodologies in the literature. The nature and prevalence of different methodological approaches has not been thoroughly examined in prior systematic reviews.

Methods

The PubMed, medRxiv and bioRxiv databases were used to identify studies that aimed at risk factor discovery and/or risk prediction model development for ICI-indu

SUBMITTER: Chen YK 

PROVIDER: S-EPMC10560723 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature