2'-Fucosyllactose (2'-FL) changes infants gut microbiota composition and their metabolism in a host-free human colonic model.

ABSTRACT:

Background

Breast milk is critical for neonates, providing the necessary energy, nutrients, and bioactive compounds for growth and development. Research indicated that human milk oligosaccharides (HMOs) have been shown to shape a beneficial gut microbiota, as well as their metabolism (e.g. short-chain fatty acids). 2'-Fucosyllactose (2'-FL) is one major HMO that composed of 30% of total HMOs.

Objectives

This study aimed to understand the impact of 2'-FL on the composition and metabolism of infant gut microbiota.

Methods

Our study utilized an in-vitro human colonic model (HCM) to investigate the host-free interactions between 2'-FL and infant gut microbiota. To simulate the infant gut microbiota, we inoculated the HCM system with eight representative bacterial species

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10560763 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature