Cancer stem cells of head and neck squamous cell carcinoma; distance towards clinical application; a systematic review of literature.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is the major pathological type of head and neck cancer (HNC). The disease ranks sixth among the most common malignancies worldwide, with an increasing incidence rate yearly. Despite the development of therapy, the prognosis of HNSCC remains unsatisfactory, which may be attributed to the resistance to traditional radio-chemotherapy, relapse, and metastasis. To improve the diagnosis and treatment, the targeted therapy for HNSCC may be successful as that for some other tumors. Nanocarriers are the most effective system to deliver the anti-cancerous agent at the site of interest using passive or active targeting approaches. The system enhances the drug concentration in HCN target cells, increases retention, and reduces toxicity to normal cells. Amo

SUBMITTER: Sun Q 

PROVIDER: S-EPMC10560931 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature