Effects of the DASH diet and losartan on serum urate among adults with hypertension: Results of a randomized trial.

ABSTRACT: Serum urate is a risk factor for hypertension and gout. The DASH diet and losartan independently lower blood pressure (BP); however, their effects on serum urate are understudied. We performed a post-hoc analysis of the DASH-losartan trial, which randomized participants with hypertension in parallel fashion to the DASH diet or a standard American diet (control) and in crossover fashion to 4-week losartan or placebo. Serum urate was measured at baseline and after each 4-week period. Diets were designed to maintain weight constant. We examined the effects of DASH (vs control) and/or losartan (vs placebo) on serum urate, overall and among those with baseline serum urate ≥6 mg/dL, using generalized estimating equations. Of 55 participants (mean age 52 years, 58% women, 64% Black), mean (±SD) b

SUBMITTER: Castilla-Ojo N 

PROVIDER: S-EPMC10560966 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature