Near-Infrared Afterglow ONOO^--Triggered Nanoparticles for Real-Time Monitoring and Treatment of Early Ischemic Stroke.

ABSTRACT: Early detection and drug intervention with the appropriate timing and dosage are the main clinical challenges for ischemic stroke (IS) treatment. The conventional therapeutic agents relay fluorescent signals, which require real-time external light excitation, thereby leading to inevitable autofluorescence and poor tissue penetration. Herein, we report endogenous peroxynitrite (ONOO^-)-activated BDP-4/Cur-CL NPs that release NIR afterglow signals (λ_max 697 nm) for real-time monitoring of the progression of ischemia reperfusion (I/R) brain injury while releasing curcumin for the safe treatment of IS. The BDP-4/Cur-CL NPs exhibited bright NIR afterglow luminescence (maximum 732-fold increase), superb sensitivity (LOD = 82.67 nM), high energy-transfer efficie

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10561133 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature