Multiomics and bioinformatics identify differentially expressed effectors in the brain of Toxoplasma gondii infected masked palm civet.

ABSTRACT:

Introduction

The masked palm civet (Paguma larvata) serves as a reservoir in transmitting pathogens, such as Toxoplasma gondii, to humans. However, the pathogenesis of T. gondii infection in masked palm civets has not been explored. We studied the molecular changes in the brain tissue of masked palm civets chronically infected with T. gondii ME49.

Methods

The differentially expressed proteins in the brain tissue were investigated using iTRAQ and bioinformatics.

Results

A total of 268 differential proteins were identified, of which 111 were upregulated and 157 were downregulated. KEGG analysis identified pathways including PI3K-Akt signaling pathway, proteoglycans in cancer, carbon metabolism, T-cell receptor signaling pathway. Combing trans

SUBMITTER: Yuan H 

PROVIDER: S-EPMC10561248 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature